Feb 2, 2017: In a paper published in the journal JAMA oncology, Doctor Raaj Mehta and colleagues from Harvard Medical School (USA) suggest that a diet rich in fibre and whole grains could influence the risk of developing colorectal cancer linked to a strain of gut bacteria called Fusobacterium nucleatum.
Fusobacterium nucleatum is an inflammatory bacterium that is thought to play a role in colorectal cancer by blocking the immune response triggered to combat tumour cells in the colon.
By studying the diets of 137,217 people over approximately 30 years, and analyzing 1000 samples from colorectal tumours and their Fusobacterium nucleatum levels, the Harvard researchers found that individuals eating diets rich in whole-grain cereals and fibre had a lower risk of developing colorectal cancer containing this particular type of bacteria.
However, the behaviour of tumours not containing Fusobacterium nucleatum was unchanged and the risk of developing colorectal cancer not containing the bacterium was not reduced.
The study concludes that, beyond this type of bacteria, dietary choices have the potential to increase or reduce cancer risk by affecting the bacteria in the digestive tract.
Colorectal cancer is the second most deadly form of cancer and the third most common form of the disease. However, if detected early, colorectal cancer can be cured in nine out of 10 cases.